Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer’s disease

We investigated the proteomic profiles of amyloid plaques (APs) from Alzheimer's disease (AD) and age-matched non-AD brains and APP/PS1 transgenic ...
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Longitudinal study of hearing loss and subjective cognitive function decline in men

We examined the relation between self-reported hearing loss, hearing aid use, and risk of subjective cognitive function (SCF) decline.
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Alzheimer’s disease and glaucoma: Look-alike neurodegenerative diseases

We read with great interest the article by Lee et al. [1] entitled “Associations between recent and established ophthalmic conditions and ...
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Early versus late MCI: Improved MCI staging using a neuropsychological approach

The Alzheimer's Disease Neuroimaging Initiative (ADNI) separates “early” and “late” mild cognitive impairment (MCI) based on a single memory test. ...
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Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr)

A small percentage of Alzheimer's disease (AD) cases are caused by genetic mutations with autosomal dominant inheritance. We report a ...
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Predicting diagnosis and cognition with 18F-AV-1451 tau PET and structural MRI in Alzheimer’s disease

The relative importance of structural magnetic resonance imaging (MRI) and tau positron emission tomography (PET) to predict diagnosis and cognition ...
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Artificially low mild cognitive impairment to normal reversion rate in the Alzheimer’s Disease Neuroimaging Initiative

We examined reasons for low mild cognitive impairment (MCI)-to-cognitively normal (CN) reversion rates in the Alzheimer's Disease Neuroimaging Initiative (ADNI).
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A rare missense variant of CASP7 is associated with familial late-onset Alzheimer’s disease

The genetic architecture of Alzheimer's disease (AD) is only partially understood.
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Dietary changes and cognition over 2 years within a multidomain intervention trial—The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

Association between healthy diet and better cognition is well established, but evidence is limited to evaluate the effect of dietary ...
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Subjective cognitive decline and rates of incident Alzheimer’s disease and non–Alzheimer’s disease dementia

In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence ...
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