Early versus late MCI: Improved MCI staging using a neuropsychological approach

The Alzheimer's Disease Neuroimaging Initiative (ADNI) separates “early” and “late” mild cognitive impairment (MCI) based on a single memory test. ...
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Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr)

A small percentage of Alzheimer's disease (AD) cases are caused by genetic mutations with autosomal dominant inheritance. We report a ...
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Predicting diagnosis and cognition with 18F-AV-1451 tau PET and structural MRI in Alzheimer’s disease

The relative importance of structural magnetic resonance imaging (MRI) and tau positron emission tomography (PET) to predict diagnosis and cognition ...
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Artificially low mild cognitive impairment to normal reversion rate in the Alzheimer’s Disease Neuroimaging Initiative

We examined reasons for low mild cognitive impairment (MCI)-to-cognitively normal (CN) reversion rates in the Alzheimer's Disease Neuroimaging Initiative (ADNI).
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A rare missense variant of CASP7 is associated with familial late-onset Alzheimer’s disease

The genetic architecture of Alzheimer's disease (AD) is only partially understood.
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Dietary changes and cognition over 2 years within a multidomain intervention trial—The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

Association between healthy diet and better cognition is well established, but evidence is limited to evaluate the effect of dietary ...
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Subjective cognitive decline and rates of incident Alzheimer’s disease and non–Alzheimer’s disease dementia

In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence ...
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Genetic screen in a large series of patients with primary progressive aphasia

Primary progressive aphasia (PPA) is a neurological syndrome, associated with both frontotemporal dementia and Alzheimer's disease, in which progressive language ...
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