Parkinsonism in MCI or mild Alzheimer’s disease
By ACA |
Examining 106 subjects aged 60-97 years, Sasaki [1] recently found parkinsonism (rigidity, resting tremor, reduced dopamine transporter in basal ganglia) in ...
Read More Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer’s disease
By ACA |
Four less well-studied but promising “emerging” cerebrospinal fluid (CSF) biomarkers are elevated in late-onset Alzheimer disease (AD): neurogranin, synaptosomal-associated protein-25 ...
Read More Failure to detect an association between self-reported traumatic brain injury and Alzheimer’s disease neuropathology and dementia
By ACA |
Recent research with neuropathologic or biomarker evidence of Alzheimer's disease (AD) casts doubt on traumatic brain injury (TBI) as a ...
Read More GeneMatch: A novel recruitment registry using at-home APOE genotyping to enhance referrals to Alzheimer’s prevention studies
By ACA |
Recruitment for Alzheimer's disease (AD) prevention research studies is challenging because of lack of awareness among cognitively healthy adults coupled ...
Read More Clinical and cortical decline in the aphasic variant of Alzheimer’s disease
By ACA |
Primary progressive aphasia (PPA) displays variable progression trajectories that require further elucidation.
Read More Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer’s disease
By ACA |
The tau protein plays a central role in Alzheimer's disease (AD), and there is huge interest in measuring tau in ...
Read More Human stem cell–derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2
By ACA |
Murine microglia expressing the Alzheimer's disease–linked TREM2R47H mutation display variable decrease in phagocytosis, while impaired phagocytosis is reported following loss ...
Read More A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium
By ACA |
We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB).
Read More Hypertension and obesity moderate the relationship between β-amyloid and cognitive decline in midlife
By ACA |
This study tested if central obesity, hypertension, or depressive symptoms moderated the relationship between β-amyloid (Aβ) and longitudinal cognitive performance ...
Read More AMYPAD Diagnostic and Patient Management Study: Rationale and design
By ACA |
Reimbursement of amyloid–positron emission tomography (PET) is lagging due to the lack of definitive evidence on its clinical utility and ...
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