Archive for March 2019
Alteration in sleep architecture and electroencephalogram as an early sign of Alzheimer’s disease preceding the disease pathology and cognitive decline
The present work aims to evaluate the significance of sleep disturbance and electroencephalogram (EEG) alteration in the early stage of Alzheimer’s disease (AD).
Read MoreStaging biomarkers in preclinical autosomal dominant Alzheimer’s disease by estimated years to symptom onset
Staging preclinical Alzheimer disease (AD) by the expected years to symptom onset (EYO) in autosomal dominant AD (ADAD) through biomarker correlations is important.
Read MoreHospitalization, surgery, and incident dementia
We evaluated whether hospitalization with or without surgery increases risk for dementia or Alzheimer’s disease.
Read More2019 Alzheimer’s disease facts and figures
This article describes the public health impact of Alzheimer’s disease (AD), including incidence and prevalence, mortality and morbidity, use and costs of care, and the overall impact on caregivers and society. The Special Report examines the use of brief cognitive assessments by primary care physicians as a tool for improving early detection of dementia. An…
Read MoreMedical and Scientific Advisory Council
Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer’s disease spectrum
We investigated relations between amyloid-β (Aβ) status, apolipoprotein E (APOE) ε4, and cognition, with cerebrospinal fluid markers of neurogranin (Ng), neurofilament light (NFL), YKL-40, and total tau (T-tau).
Read MoreThe role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer’s disease
Little is known about the role of age on neurodegeneration and protein deposition in atypical variants of Alzheimer’s disease (AD).
Read MoreA randomized clinical trial to evaluate home-based assessment of people over 75 years old
There is an unmet need for effective methods for conducting dementia prevention trials.
Read MorePrimary age-related tauopathy (PART) and Alzheimer’s disease (AD)
Bell et al. [1] recently compared neuropathologic, genetic, and cognitive profiles in 40 primary age-related tauopathy (PART) and 130 Alzheimer’s disease (AD) cases aged ≥85 years. PART, representing 22% of this consecutive oldest-old autopsy series, differed from classical AD by significantly slower rates of cognitive impairment, lower frequency of apolipoprotein E (APOE) ε4 (4.1% vs. 17.6%) but overrepresented…
Read MoreDetecting both current and prior Helicobacter pylori infection is important to assess its impact on dementia
We read with great interest the article written by Fani et al. on the association between Alzheimer’s disease and Helicobacter pylori infection studied on a population-based cohort (Rotterdam study) [1]. The authors did not find any association between the two diseases, that is, H. pylori infection was not associated with an increased dementia incidence after a…
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