Detecting both current and prior Helicobacter pylori infection is important to assess its impact on dementia

We read with great interest the article written by Fani et al. on the association between Alzheimer’s disease and Helicobacter pylori infection studied on a population-based cohort (Rotterdam study) [1]. The authors did not find any association between the two diseases, that is, H. pylori infection was not associated with an increased dementia incidence after a mean follow-up of 10 years in more than 4000 participants. As the authors mentioned in their article, we previously carried out a similar study (PAQUID—“Personnes Agées QUID” study) on 603 noninstitutionalized individuals aged 65 years and older living in the southwest of France followed from 1989 to 2008 with opposite conclusions [2].