Primary age-related tauopathy (PART) and Alzheimer’s disease (AD)

Bell et al. [1] recently compared neuropathologic, genetic, and cognitive profiles in 40 primary age-related tauopathy (PART) and 130 Alzheimer’s disease (AD) cases aged ≥85 years. PART, representing 22% of this consecutive oldest-old autopsy series, differed from classical AD by significantly slower rates of cognitive impairment, lower frequency of apolipoprotein E (APOE) ε4 (4.1% vs. 17.6%) but overrepresented APOE ε2 (12.2% vs. 5.3%), and significantly less extensive tau lesions beyond the medial temporal lobe, over 60% of definite PART subjects corresponding to Braak tau stage IV.